ATOVAQUONE–PROGUANIL: USES, MECHANISM OF ACTION, ADULT AND PAEDIATRIC DOSING, MALARIA TREATMENT AND PREVENTION
PART 1 Atovaquone–proguanil is a fixed-dose antimalarial combination widely used for both treatment of uncomplicated malaria and malaria prevention in travellers . It is particularly useful because it is generally well tolerated, has a relatively short prophylaxis period after leaving a malaria area, and attacks the parasite through two complementary mechanisms. The adult-strength tablet contains: Atovaquone 250 mg + proguanil hydrochloride 100 mg. The paediatric tablet contains: Atovaquone 62.5 mg + proguanil hydrochloride 25 mg. What does atovaquone–proguanil treat? It is an important option for uncomplicated Plasmodium falciparum malaria , including infections acquired in many chloroquine-resistant areas. Current CDC guidance includes atovaquone–proguanil among the preferred oral options for appropriate uncomplicated malaria. It can also be used as: a complete oral treatment regimen for appropriate uncomplicated malaria; follow-on oral treatment after IV artesunate in severe malar...